杭州普雷化工有限公司

bulk drugs & intermediates

PRODUCT LIST

Abemaciclib Intermediates:

6-(2-Chloro-5-Fluoro-4-Pyrimidinyl)-4-Fluoro-2-Methyl-1-(1-Methylethyl)-1H-Benzimidazole(CAS:1231930-42-9)

4-fluoro-2-methyl-1-(1-methylethyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole(CAS:1231930-37-2)

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole(CAS:1231930-33-8)

6-Bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole(CAS:1038408-36-4)

1-[(6-Bromo-3-pyridinyl)methyl]-4-ethylpiperazine(CAS:1231930-25-8)

5-((4-Ethylpiperazin-1-Yl)Methyl)Pyridin-2-Amine  (CAS: No: 1180132-17-5 )

Acalabrutinib Intermediates:

[4-(2-pyridylcarbamoyl)phenyl]boronic acid(CAS: 850568-25-1 )

3-Chloropyrazin-2-yl)MethanaMine hydrochloride (CAS: 939412-86-9 )

N-(Pyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide(CAS: 1383385-64-5)

(S)-Benzyl 2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate(CAS: 1420478-88-1)

(3-chloropyrazin-2-yl)methanamine hydrochloride    (CAS: 867165-53-5)

Alectinib Intermediate:

tert-butyl 6-cyano-2-(2-(4-ethyl-3-iodophenyl)propan-2-yl)-1H-indole-3-carboxylate (CAS: 1256584-75-4 )

2-(4-Ethyl-3-iodophenyl)-2-methylpropanoic acid(CAS: 1256584-73-2)

(3-chloropyrazin-2-yl)methanamine hydrochloride    (CAS: 867165-53-5)

Anagliptin Intermediates:

(S)-1-(2-Chloroacetyl)pyrrolidine-2-carbonitrile  (CAS: 207557-35-5)

2-methylpyrazolo [1, 5-a] pyrimidine-6-carboxylic acid (CAS:739364-95-5)

Ethyl-2-formyl-3-oxopropanoate (CAS:80370-42-9)

1,2-diamino-2-methylpropane(CAS:811-93-8)

Apalutamide Intermediates:

5-Amino-3-trifluoromethyl-pyridine-2-carbonitrile (CAS: 573762-62-6)

5-Nitro-3-trifluoroMethylpyridine-2-carbonitrile(CAS: 573762-57-9)

1-Aminocyclobutanecarboxylic acid(CAS: 22264-50-2)

N-Boc-1-aminocyclobutanecarboxylic acid (CAS:120728-10-1)

5-isothiocyanato-3-(trifluoromethyl)picolinonitrile( CAS:951753-87-0)

4-[(1-Cyanocyclobutyl)amino]-2-fluoro-N-methylbenzamide (CAS:915087-26-2)

Baloxavir Intermediates:

7,8-Difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-ol  (CAS:1985607-83-7)
(R)-7-(Benzyloxy)-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione
(CAS:1985607-70-2)

3-Benzyloxy-4-oxo-4H-pyran-2-carboxylic acid (CAS:1119736-16-2)

Bictegravir Intermediates:

(1R,3S)-3-AMinocyclopentanol hydrochloride(CAS:1279032-31-3)

2,4,6-trifluorobenzylaminine(CAS:214759-21-4)

1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid (CAS: 1335210-23-5)

Binimetinib Intermediates:

197520-71-1

284030-57-5

284030-58-6

391212-29-6

1023742-13-3

105931-73-5

918321-20-7

Darolutamide Intermediates:

5-Acetyl-1H-Pyrazole-3-Carboxylic Acid (CAS: 1297537-45-1 )

2-Chloro-4-(1H-pyrazol-3-yl)benzonitrile  (CAS: 1297537-37-1)

(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chlorobenzonitrile (CAS:1297537-41-7)

(S)-3-acetyl-N-(1-(3-(3-chloro-4-cyano-phenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-pyrazole-5-carboxamide (CAS:1297537-33-7)

Darunavir Intermediates:

(3aR,4S,6aS)-4-methoxy tetrahydro-furo[3,4-b]furan-2-one (CAS: 866594-60-7)

4-Amino-N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(2-methylpropyl)benzenesulfonamide(CAS:169280-56-2)

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol  (CAS:156928-09-5)

Carbonic acid 2,5-dioxo-1-pyrrolidinyl [(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl] ester  (CAS:253265-97-3)

Dexmedetomidine Intermediates:

1-(2,3-Dimethylphenyl)ethyl chloride    (CAS: 60907-88-2)

Dolutegravir Intermediates:

(R)-3-amino-butan-1-ol (CAS: 61477-40-5)

CAS: 1335210-23-5

Doluxetine Intermediates:

CAS: 116539-55-0

(S)-3-(MethylaMino)-1-(2-thienyl)-1-propanol

CAS: 132335-44-5

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

CAS: 321-38-0

1-Fluoronaphthalene

Edoxaban Intermediates:

Ethyl-2-[(5-chloropyridin-2-yl)amino]-2-oxoacetate hydrochloride (CAS:1243308-37-3)

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride (CAS:720720-96-7)

(1S,2R,4S)-2-[(tert-Butoxycarbonyl)Amino ]-4-[( dimethylamino)carbonyl]- cyclohexyl ammonia oxalate (CAS:1210348-34-7)

Elagolix Intermediates:

2-​Fluoro-​6-​(trifluoromethyl)​benzenemethanamine (CAS:239087-06-0 )

N-​[[2-​Fluoro-​6-​(trifluoromethyl)​phenyl]​methyl]​urea (CAS:830346-46-8 )

2-Fluoro-3-methoxybenzeneboronic acid (CAS:352303-67-4 )

1-(2-Fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H- pyrimidine-2,4-dione  (CAS: 830346-47-9 )

5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione (CAS:830346-48-0 )

1-(2-fluoro-6-(trifluoromethyl)benzyl)-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione (CAS:1150560-54-5 )

Empaliglozin Intermediates:

5-bromo-2-chlorophenyl)(4-fluorophenyl)methanone (CAS: 915095-85-1)

(S)-(+)-3-Hydroxytetrahydrofuran  (CAS:86087-23-2)

(3S)-3-[4-[(5-bromo-2-chlorophenyl)methyl]phenoxy]oxolane (CAS:915095-89-5)

(S)-3-(4-(2-chloro-5-iodobenzyl)phenoxy)-tetrahydrofuran (CAS:915095-94-2)

(1S)-1,5-anhydro-2,3,4,6-tetra-O-acteyl-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydrofu-ran-3-yl]oxy]phenyl] methyl]phenyl]-D-Glucitol (CAS:915095-99-7)

Encorafenib Intermediates:

(S)-Methyl 1-aMinopropan-2-ylcarbaMate hydrochloride (CAS: 1229025-32-4 )

3-amino-1-isopropyl-1H-pyrazole-4-carbonitrile (CAS: 89897-29-0 )

1-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)ethanone (CAS: 1269440-49-4 )

PyriMidine, 2-chloro-4-[3-iodo-1-(1-Methylethyl)-1H-pyra

zol-4-yl]- (CAS: 1269440-58-5 )

Filgotinib Intermediates:

5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-amine (CAS:1010120-55-4)

cyclopropanecarboxylic acid (5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amide (CAS:1142943-96-1)

5-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine (CAS:175965-64-7)

2-(4-(Bromomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS:138500-85-3)

Thiomorpholine 1,1-Dioxide Hydrochloride (CAS:59801-62-6)

4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-thiomorpholine-1,1-dioxide (CAS:1092563-25-1)

Larotrectinib Intermediates:

CAS:1223403-58-4

CAS:1218935-59-1

CAS:100243-39-8

CAS:1363380-51-1

Lbrutinib Intermediates:

(S)-1-Boc-3-hydroxypiperidine (CAS:143900-44-1)

3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS:330786-24-8)

4-PHENOXYPHENYLBORONIC ACID  (CAS:51067-38-0)

Lenvatinib Intermediates:

4-chloro-7-methoxy quinoline-6-carboxamide (CAS: 417721-36-9)

4-amino-3-chlorophenol hydrochloride (CAS: 52671-64-4)

Lorlatinib Intermediates:

Ethyl 1,3-dimethyl-1H-pyrazole-5-carboxylate (CAS: 5744-40-1)

1-(5-Fluoro-2-iodophenyl)ethanone (CAS : 914225-70-0)

Memantine HCL Intermediates:
1,3-dimethyl adamantine  (CAS: 702-79-4)
Midostaurin Intermediates:

Staurosporine

Niraparib Intermediates:

(S)-tert-butyl 3-(4-aMinophenyl)piperidine-1-carboxylate (CAS: 1171197-20-8 )

3-Formyl-2-nitrobenzoic acid methyl ester (CAS:138229-59-1)

Olmesartan Intermediates:

DMDO-CL  (CAS: 80841-78-7)
[5-(1-Hydroxyl-1-methylethyl)-2-propyl-imidazol-4-yl]carboxylic acid ethyl ester (CAS: 144689-93-0)

Osimertinib Intermediates:

4-fluoro-2-Methoxy-5-nitroaniline(CAS: 1075705-01-9)

3-(2-chloropyriMidin-4-yl)-1-Methylindole(CAS:1032452-86-0 )

CAS: 1421372-67-9

CAS: 1421372-94-2

CAS: 1421372-66-8

Relugolix Intermediates:

ethyl 2-((ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate (CAS: 308831-93-8)

6-​Methoxy-​3-pyridazinamine, hydrochloride (1:1) (CAS: 1589503-98-9)

Remdesivir Intermediates:

CAS:55094-52-2
CAS:159326-68-8
CAS:946511-97-3
CAS:937046-98-5
CAS:1911578-98-7
CAS:1191237-80-5
CAS:1354823-36-1
CAS:1191237-69-0
CAS:1770840-43-1

Ribociclib Intermediates:

2-Chloro-7-cyclopentyl-n,n-dimethyl-7h-pyrrolo[2,3d]pyrimidine-6-carboxamide(CAS: CAS: 1211443-61-6)

2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid(CAS:CAS: 1211443-58-1 )

1-boc-4-(6-aminopyridin-3-yl)piperazine(CAS:CAS: 571188-59-5)

Rucaparib Intermediates:

8-Fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one (CAS: 1408282-26-7)

Roxadustat Intermediates:

5-phenoxyisobenzofuran-1(3H)-one (CAS:57830-14-5 )

Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate (CAS:1455091-10-7 )

Methyl 1,4-dihydroxy-7-phenoxyisoquinoline-3-carboxylate (CAS:1421312-32-4 )

Ethyl 1,4-dihydroxy-7-phenoxyisoquinoline-3-carboxylate

4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester (CAS:1421312-34-6)

Siponimod Intermediates:

4-Bromomethyl-1-cyclohexyl-2-trifluoromethylbenzene (CAS:800381-60-6)

4-Cyclohexyl-3-trifluoromethylbenzoic acid (CAS:916806-97-8 )

Solifenacin Intermediates:

(R)-(-)-3-Quinuclidinol(CAS:25333-42-0)

Ticagrelor Intermediates:

2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)ethanol L-tataric acid(CAS:376608-65-0 )
4,6-dichloro-2-(propylsulfanyl)pyrimidin-5-amine(CAS:145783-15-9)

(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine hydrochloride(CAS:1156491-10-9)

N-1 (CAS: 274693-26-4)

Tofacitinib Intermediates:

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine   (CAS: 3680-69-1)

BAP-L-Tartrate (CAS: 477600-71-8)

Upadacitinib Intermediates:

(3R,4S)-3-(2-Bromoacetyl)-4-ethyl-1-pyrrolidinecarboxylic acid phenylmethyl ester   (CAS:1428243-26-8)

5-Bromo-4,7-diazaindole   (CAS:875781-43-4)

Section

API

Product Name Documents
Abiraterone Acetate DDMF/GMP
Adagrasib Acetate DMF
Apixaban Acetate DMF/CEP/WC
Apalutamide DMF
Avatrombopag Maleate DMF
Baloxavir DMF Will be ready in 2024
Brivaracetam DMF/WC
Caffeine CEP/USFDA/FCC/COS/KOS HER/HALAL
Celecoxib DMF/GMP
Cinacalcet Hydrochloride DMF/GMP
Dapagliflozin DMF/GMP
Diquafosol tetrasodium DMF
Darunavir DMF
Empagliflozin DMF/GMP
Enzalutamide DMF
Ezetimibe DMF/WC
Fulvestrant DMF/CEP
Fimasartan DMF will be ready 2024
Febuxostat GMP/DMF
Finerenone DMF/WC
Gadobutrol DMF
Gadolinium DOTA meglumine DMF
Gadoteridol DMF
Iguratimod DMF will be ready in 2023
Isavuconazole DMF
Linagliptin DMF
Minocycline Hydrochloride EU-GMP/WC
Netupitant DMF
Nintedanib esylate DMF/CEP
Niraparib DMF
Palbociclib DMF/WC/GMP
Pemetrexed Disodium DMF/CEP/GMP
Resmetirom R&D Stage
Roxadustat GMP/DMF/WC
Sacubitril/Valsartan DMF
Semaglutide DMF /CEP/WC/GMP
Sitagliptin phosephate DMF
Sugammadex Sodium DMF/WC
Teicoplanin EU-GMP/EIR/WC
Terbinafine Hydrochloride CEP
Tegoprazan DMF
Vancomycin Hydrochloride USDMF/CEP/DMF/WC
Vonoprazan Fumarate DMF/WC
Finerenone GMP/DMF
Relugolix GMP/DMF
Rimegepant Local GMP/DMF
Vibegron DMF
Ubrogepant DMF
Upadacitinib DMF
Deucravactinib DMF

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